Heart disease
A small difference in inherited DNA can put people at a heightened risk of stroke and heart disease, according to new research. It is hoped the discovery could lead to advances in medical research and an understanding of the mechanism that links the mutation to the illnesses affecting individuals.
The study, which was carried out by the Yale University School of Medicine, indicated that tiny mutations in the genes of mitochondria contributed to a wide range of life-shortening risk factors such as high blood pressure and high cholesterol.
The researchers focused on the medical histories of a single family and found evidence of a genetic link to abnormalities passed only from the mother.
"In total, we studied 142 relatives. When we looked at the pattern of these pathologies we found there was an excess of affected individuals on the maternal lineage," said Dr Richard Lifton, project leader.
The study also found the same family members were at greater risk from hearing loss, migraine and weakened heart muscles, all conditions linked to mutations in mitochondrial DNA. While the findings are significant, Lifton acknowledged that further research needs to be carried out.
