Stroke: New research shows hidden risk of hormone replacement therapy
Hormone replacement therapy (HRT) may increase the risk of stroke by almost a third, according to a review of clinical trials.
Researchers at the University of Nottingham reviewed the results of 28 trials involving almost 40,000 patients. They concluded that the overall risk of stroke increased by 29%, with ischaemic stroke, the type caused an insufficient blood supply to the brain, found to be a particularly high risk. The severity of the stroke also increased with HRT use.
The findings support previous studies that have linked HRT to an increased risk of breast cancer and heart disease, as well as stroke.
Lead researcher, Professor Philip Bath, said it was unclear why HRT should increase the risk of stroke and its severity when some studies had suggested it might have a protective effect.
Responding to the findings, a spokesperson for The Stroke Association, said: "Studies have shown no cardiovascular benefit from HRT and this review now shows that HRT can also not be recommended as a preventative measure for stroke. We are pleased that the existing evidence on the relationship between HRT and stroke has now been consolidated."
The review will no doubt cause further anxiety for women who use HRT to treat symptoms of the menopause such as insomnia and head-aches. The therapy has also been prescribed to women to reduce the risk of osteoporosis although this practice is now discouraged.
The Royal College of Obstetricians and Gynaeco-logists has recommended HRT is used as a short-term measure to alleviate menopausal symptoms, while the Department of Health has also stressed the importance of using the lowest possible dose for the shortest possible time.
